Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

align
annotate
download

Concept information

Inorganic Chemicals > Coordination Complexes > Oxaliplatin
Organic Chemicals > Coordination Complexes > Oxaliplatin

Preferred term

Oxaliplatin  

Type

  • mesh:Descriptor

Definition

  • An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.

Broader concept

Entry terms

  • 04ZR38536J
  • 1,2-Diaminocyclohexane Platinum Oxalate
  • 1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II)
  • 61758-77-8 ((SP-4-2-(1S-trans))-isomer)
  • 61913-68-6 ((SP-4-3-(cis))-isomer)
  • L-OHP Cpd
  • Oxalato-(1,2-cyclohexanediamine)platinum II
  • Oxaliplatine
  • Oxaliplatin, (SP-4-2-(1R-trans))-isomer
  • Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
  • Platinum(II)-1,2-cyclohexanediamine Oxalate

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Oxaliplatine

    French

  • 04ZR38536J
  • 61758-77-8 ((SP-4-2-(1S-trans))-isomer)
  • 61913-68-6 ((SP-4-3-(cis))-isomer)

URI

http://data.loterre.fr/ark:/67375/JVR-XKTP00R8-V

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/9/18, last modified 7/5/19