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Immune System Phenomena > Immunogenetic Phenomena > Gene Rearrangement, B-Lymphocyte > Gene Rearrangement, B-Lymphocyte, Heavy Chain > Immunoglobulin Class Switching
Genetic Phenomena > Gene Rearrangement > Gene Rearrangement, B-Lymphocyte > Gene Rearrangement, B-Lymphocyte, Heavy Chain > Immunoglobulin Class Switching

Preferred term

Immunoglobulin Class Switching  

Type

  • mesh:Descriptor

Definition

  • Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.

Broader concept

Related concepts

Entry terms

  • Class Switching
  • Ig Class Switching
  • Isotype Switching

Allowable Qualifier(s)

In other languages

  • Commutation de classe des immunoglobulines

    French

  • Commutation d'isotype
  • Commutation de classe
  • Commutation de classe des Ig
  • Commutation isotypique
  • Commutation isotypique des Ig
  • Commutation isotypique des immunoglobulines
  • Switch isotypique

URI

http://data.loterre.fr/ark:/67375/JVR-XKXHNXDL-D

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RDF/XML TURTLE JSON-LD Created 6/17/93, last modified 7/5/19