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... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > GTP-Binding Protein Regulators > Guanine Nucleotide Exchange Factors > T-Lymphoma Invasion and Metastasis-inducing Protein 1
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > GTP-Binding Protein Regulators > Guanine Nucleotide Exchange Factors > T-Lymphoma Invasion and Metastasis-inducing Protein 1

Preferred term

T-Lymphoma Invasion and Metastasis-inducing Protein 1  

Type

  • mesh:Descriptor

Definition

  • A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.

Broader concept

Related concepts

Entry terms

  • TIAM-1 Protein
  • TIAM1 Protein

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-XM411M61-C

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 6/29/17