Concept information
Preferred term
Podophyllotoxin
Type
-
mesh:Descriptor
Definition
- A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Broader concept
Narrower concepts
Entry terms
- 4375-06-8 ((5R-(5 alpha,5a alpha,8a alpha,9 beta))-isomer)
- 4375-07-9 ((5R-(5 alpha,5a beta,8a alpha,9 beta))-isomer)
- 477-47-4 ((5R-(5 alpha,5a alpha,8a alpha,9 alpha))-isomer)
- 518-28-5 (Podophyllotoxin)
- 55568-79-1 ((5R-(5 alpha,5a alpha,8a beta,9 alpha))-isomer)
- Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9alpha))-
- L36H50F353
- Podofilox
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
4375-06-8 ((5R-(5 alpha,5a alpha,8a alpha,9 beta))-isomer)
-
4375-07-9 ((5R-(5 alpha,5a beta,8a alpha,9 beta))-isomer)
-
477-47-4 ((5R-(5 alpha,5a alpha,8a alpha,9 alpha))-isomer)
-
518-28-5 (Podophyllotoxin)
-
55568-79-1 ((5R-(5 alpha,5a alpha,8a beta,9 alpha))-isomer)
-
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9alpha))-
-
L36H50F353
URI
http://data.loterre.fr/ark:/67375/JVR-XNGT3QH2-X
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