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Concept information

Biological Factors > Intercellular Signaling Peptides and Proteins > Cytokines > Tumor Necrosis Factors > Cytokine TWEAK
... > Amino Acids, Peptides, and Proteins > Peptides > Intercellular Signaling Peptides and Proteins > Cytokines > Tumor Necrosis Factors > Cytokine TWEAK
... > Amino Acids, Peptides, and Proteins > Proteins > Intercellular Signaling Peptides and Proteins > Cytokines > Tumor Necrosis Factors > Cytokine TWEAK

Preferred term

Cytokine TWEAK  

Type

  • mesh:Descriptor

Definition

  • A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.

Broader concept

Entry terms

  • Apo3 Ligand
  • TNF-Related Weak Inducer of Apoptosis
  • Tumor Necrosis Factor Ligand Superfamily Member 12
  • TWEAK Cytokine

Allowable Qualifier(s)

In other languages

  • Cytokine TWEAK

    French

  • Inducteur faible d'apoptose apparenté au TNF
  • Ligand Apo3
  • Membre-12 de la superfamille des ligands TNF
  • Membre-12 de la superfamille des TNF ligands
  • Membre-12 de la superfamille du facteur de nécrose tumorale

URI

http://data.loterre.fr/ark:/67375/JVR-XQ3PHBXP-4

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 2/24/17