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Concept information

Amino Acids, Peptides, and Proteins > Proteins > Phosphoproteins > Focal Adhesion Kinase 1
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Focal Adhesion Protein-Tyrosine Kinases > Focal Adhesion Kinase 1
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Focal Adhesion Protein-Tyrosine Kinases > Focal Adhesion Kinase 1
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein-Tyrosine Kinases > Focal Adhesion Protein-Tyrosine Kinases > Focal Adhesion Kinase 1

Preferred term

Focal Adhesion Kinase 1  

Type

  • mesh:Descriptor

Definition

  • A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.

Broader concept

Entry terms

  • Endogenous Substrate pp120
  • Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
  • p125FAK Protein
  • Protein Tyrosine Kinase 2

Allowable Qualifier(s)

In other languages

  • Focal adhesion kinase 1

    French

  • Focal adhesion-associated protein-tyrosine kinase pp125FAK
  • Kinase d'adhésion focale 1
  • Protéine p125FAK

URI

http://data.loterre.fr/ark:/67375/JVR-XW0JFMF6-G

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RDF/XML TURTLE JSON-LD Created 6/30/05, last modified 5/21/21