Concept information
Preferred term
Zalcitabine
Type
-
mesh:Descriptor
Definition
- A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Broader concept
Narrower concepts
Entry terms
- 2',3'-Dideoxycytidine
- 6L3XT8CB3I
- 7481-89-2 (Zalcitabine)
- Cytidine, 2',3'-dideoxy-
- ddC (Antiviral)
- Dideoxycytidine
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
6L3XT8CB3I
-
7481-89-2 (Zalcitabine)
-
Cytidine, 2',3'-dideoxy-
-
Didésoxycytidine
URI
http://data.loterre.fr/ark:/67375/JVR-Z0HF807D-C
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