Concept information
Preferred term
Giant Cells
Type
-
mesh:Descriptor
Definition
- Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
Broader concept
Narrower concepts
Entry terms
- Giant Cells, Multinucleated
- Multinucleated Giant Cells
- Polykaryocytes
- Syncytia
- Syncytium
Allowable Qualifier(s)
- chemistry (Qualifier)
- classification (Qualifier)
- cytology (Qualifier)
- drug effects (Qualifier)
- enzymology (Qualifier)
- immunology (Qualifier)
- metabolism (Qualifier)
- microbiology (Qualifier)
- parasitology (Qualifier)
- pathology (Qualifier)
- physiology (Qualifier)
- radiation effects (Qualifier)
- transplantation (Qualifier)
- ultrastructure (Qualifier)
- virology (Qualifier)
In other languages
-
French
-
Cellule géante
-
Cellules géantes multinucléées
-
Cellules géantes plurinucléées
-
Plasmodes
-
Polycaryocyte
-
Polycaryocytes
-
Syncytium cellulaire
-
Syncytiums cellulaires
URI
http://data.loterre.fr/ark:/67375/JVR-Z2XBB964-5
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