Concept information
Preferred term
2',5'-Oligoadenylate Synthetase
Type
-
mesh:Descriptor
Definition
- An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.
Broader concept
Entry terms
- (2'-5')An Polymerase
- 2-5A Synthetase
- 2,5 Oligoadenylate Polymerase
- 2',5'-Oligoadenylate Polymerase
- 2,5 Oligoadenylate Synthetase
- 2',5'-Oligo(A) Polymerase
- 2',5'-Oligo(A) Synthetase
- ATP-(2'-5')oligo(A)adenylyltransferase
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
URI
http://data.loterre.fr/ark:/67375/JVR-ZDN2HF29-0
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