Concept information
Preferred term
5-Aminolevulinate Synthetase
Type
-
mesh:Descriptor
Definition
- An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Broader concept
Entry terms
- 5-Aminolevulinate Synthase
- 9037-14-3 (CAS RN)
- Aminolevulinic Acid Synthetase
- delta-Aminolevulinate Synthase
- delta-Aminolevulinic Acid Synthetase
- Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating)
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
9037-14-3 (CAS RN)
-
Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating)
URI
http://data.loterre.fr/ark:/67375/JVR-ZHWVGWBS-L
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