Concept information
Amino Acids, Peptides, and Proteins
Peptides
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
Preferred term
eIF-2 Kinase
Type
-
mesh:Descriptor
Definition
- A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Broader concept
Entry terms
- DAI Protein Kinase
- Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
- Double Stranded RNA-Dependent Kinase (dsl)
- dsRNA-Activated Inhibitor
- DSRNA-Dep Protein Kinase
- eIF-2alpha Kinase
- eRF, eIF-2 Recycling Factor
- Eukaryotic Initiation Factor 2alpha Kinase
- Heme-Controlled Inhibitor
- Heme Controlled Repressor
- Heme-Controlled Translational Repressor
- Heme-Regulated eIF-2alpha Kinase
- Hemin Controlled Repressor
- Hemin-Controlled Translational Repressor
- p65 Kinase
- p68 Kinase
- P68 Protein Kinase
- Protein Kinase PKR
- Protein Kinase, RNA Activated
- RNA-Dependent Protein Kinase
- Self-Phosphorylating Protein Kinase
- TIK Kinase
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
p68 kinase
-
Protéine kinase ARN-dépendante
-
Protéine kinase PKR
-
Protéine-kinase activée
-
Protéine-kinase ARN-dépendante
-
Protéine-kinase PKR
URI
http://data.loterre.fr/ark:/67375/JVR-ZNMTQFS4-G
{{label}}
{{#each values }} {{! loop through ConceptPropertyValue objects }}
{{#if prefLabel }}
{{/if}}
{{/each}}
{{#if notation }}{{ notation }} {{/if}}{{ prefLabel }}
{{#ifDifferentLabelLang lang }} ({{ lang }}){{/ifDifferentLabelLang}}
{{#if vocabName }}
{{ vocabName }}
{{/if}}