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Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > High-Temperature Requirement A Serine Peptidase 2
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > High-Temperature Requirement A Serine Peptidase 2
Amino Acids, Peptides, and Proteins > Proteins > Mitochondrial Proteins > High-Temperature Requirement A Serine Peptidase 2
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Serine Proteases > Serine Endopeptidases > High-Temperature Requirement A Serine Peptidase 2
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Serine Endopeptidases > High-Temperature Requirement A Serine Peptidase 2
Amino Acids, Peptides, and Proteins > Proteins > Parkinson Disease Associated Proteins > High-Temperature Requirement A Serine Peptidase 2

Preferred term

High-Temperature Requirement A Serine Peptidase 2  

Type

  • mesh:Descriptor

Definition

  • A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.

Broader concept

Related concepts

Entry terms

  • HtrA2 Protease
  • HtrA Serine Peptidase 2
  • Omi Serine Protease
  • Serine Protease HTRA2
  • Serine Protease Omi

Allowable Qualifier(s)

In other languages

  • High-temperature requirement A serine peptidase 2

    French

  • Protéase HTRA2
  • Sérine peptidase A2 requise à haute température
  • Sérine peptidase A2 requise à température élevée
  • Sérine peptidase HtrA2
  • Sérine protéase A2 requise à haute température
  • Sérine protéase A2 requise à température élevée
  • Serine protease HTRA2
  • Sérine protéase HTRA2
  • Sérine protéase Omi
  • Sérine protéinase A2 requise à haute température

URI

http://data.loterre.fr/ark:/67375/JVR-ZTRXT0MG-0

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 6/28/21