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... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structural Elements > Amino Acid Motifs > Immunoreceptor Tyrosine-Based Activation Motif
... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structure, Secondary > Amino Acid Motifs > Immunoreceptor Tyrosine-Based Activation Motif

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Immunoreceptor Tyrosine-Based Activation Motif  

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Tipo

  • mesh:Descriptor

Definición

  • A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.

Concepto genérico

Etiquetas alternativas

  • Immune Receptor Tyrosine-Based Activation Motif
  • Immuno-Receptor Tyrosine-Based Activation Motif

En otras lenguas

URI

http://data.loterre.fr/ark:/67375/JVR-BPP66K9M-6

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