: MeSH: Senescence-Associated Secretory Phenotype

Cell Physiological Phenomena > Cellular Senescence > Senescence-Associated Secretory Phenotype

Physiological Phenomena > Growth and Development > Aging > Cellular Senescence > Senescence-Associated Secretory Phenotype

Senescence-Associated Secretory Phenotype

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A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders.

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