Concept information
Término preferido
Cardiac Glycosides
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Tipo
-
mesh:Descriptor
Definición
- Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Concepto genérico
Conceptos específicos
Etiquetas alternativas
- Cardiac Glycoside
- Cardiotonic Steroid
- Cardiotonic Steroids
En otras lenguas
-
francés
-
Hétérosides cardiotoniques
URI
http://data.loterre.fr/ark:/67375/JVR-C1ZWPH34-6
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