: MeSH: Multiple Endocrine Neoplasia Type 2b

Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Genetic Diseases, Inborn > Neoplastic Syndromes, Hereditary > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2b

Neoplasms > Neoplastic Syndromes, Hereditary > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2b

Endocrine System Diseases > Endocrine Gland Neoplasms > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2b

Neoplasms > Neoplasms by Site > Endocrine Gland Neoplasms > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2b

Neoplasms > Neoplasms, Multiple Primary > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2b

Multiple Endocrine Neoplasia Type 2b

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Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.

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