Concept information
Término preferido
Synucleinopathies
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Tipo
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mesh:Descriptor
Definición
- Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.
Concepto genérico
Conceptos específicos
Etiquetas alternativas
- alpha Synuclein Pathology
- alpha-Synucleinopathies
- a-Synucleinopathies
En otras lenguas
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francés
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alpha-Synucléinopathies
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Pathologie de l'alpha-synucléine
URI
http://data.loterre.fr/ark:/67375/JVR-D9C8K52X-X
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