: MeSH: Carbonic Anhydrase IX

Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Carbonic Anhydrase IX

Biological Factors > Antigens > Antigens, Neoplasm > Carbonic Anhydrase IX

... > Lyases > Carbon-Oxygen Lyases > Hydro-Lyases > Carbonic Anhydrases > Carbonic Anhydrase IX

Carbonic Anhydrase IX

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A carbonic anhydrase and transmembrane protein that consists of an N-terminal PROTEOGLYCAN-like domain, a catalytic region, a single-pass transmembrane domain, and a short intracellular tail. It functions as a dimer and is expressed primarily by cells of the GASTROINTESTINAL TRACT; BILE DUCT EPITHELIUM; and GALL BLADDER. It is expressed at high levels in many solid tumors, especially CLEAR CELL RENAL CARCINOMA, in response to CELL HYPOXIA.

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