: MeSH: Hypoaldosteronism

Endocrine System Diseases > Adrenal Gland Diseases > Adrenal Insufficiency > Hypoaldosteronism

Hypoaldosteronism

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A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS. A selective aldosterone deficiency resulting from diminished RENIN-generated ANGIOTENSIN II, a key stimulus to aldosterone secretion. Previously, it was called type IV renal tubular acidosis.

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