: MeSH: Clonal Hematopoiesis

Circulatory and Respiratory Physiological Phenomena > Blood Physiological Phenomena > Hematopoiesis > Clonal Hematopoiesis

Cell Physiological Phenomena > Cell Differentiation > Hematopoiesis > Clonal Hematopoiesis

Cell Physiological Phenomena > Clonal Evolution > Clonal Hematopoiesis

Genetic Phenomena > Clonal Evolution > Clonal Hematopoiesis

Clonal Hematopoiesis

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Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).

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