: MeSH: CD40 Antigens

... > Receptors, Cell Surface > Receptors, Immunologic > Receptors, Cytokine > Receptors, Tumor Necrosis Factor > CD40 Antigens

Biological Factors > Immune Checkpoint Proteins > CD40 Antigens

Amino Acids, Peptides, and Proteins > Proteins > Immune Checkpoint Proteins > CD40 Antigens

... > Antigens > Antigens, Surface > Antigens, Differentiation > Antigens, Differentiation, B-Lymphocyte > CD40 Antigens

Biological Factors > Biomarkers > Antigens, Differentiation > Antigens, Differentiation, B-Lymphocyte > CD40 Antigens

CD40 Antigens

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Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

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