: MeSH: Presenilin-1

Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Presenilins > Presenilin-1

Presenilin-1

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Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.

http://data.loterre.fr/ark:/67375/JVR-HL9KWSNH-T

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