Concept information
Término preferido
Nogo Proteins
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Tipo
-
mesh:Descriptor
Definición
- Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
Concepto genérico
Etiquetas alternativas
- Nogo Protein
- Reticulon-4 Protein
En otras lenguas
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francés
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Protéine Nogo
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Protéine réticulon-4
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Réticulon-4
URI
http://data.loterre.fr/ark:/67375/JVR-HQJ88DLR-P
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