: MeSH: GRB2 Adaptor Protein

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > GRB2 Adaptor Protein

Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > GRB2 Adaptor Protein

Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > GRB2 Adaptor Protein

GRB2 Adaptor Protein

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A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS). Grb3-3 is a natural isoform of GRB2 PROTEIN with a deletion in the SH2 DOMAIN. It acts as a dominant negative protein over GRB2, suppressing proliferative signals. It has also been implicated in APOPTOSIS.

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