: MeSH: Heavy Chain Disease

Hemic and Lymphatic Diseases > Lymphatic Diseases > Lymphoproliferative Disorders > Heavy Chain Disease

Immune System Diseases > Immunoproliferative Disorders > Lymphoproliferative Disorders > Heavy Chain Disease

Hemic and Lymphatic Diseases > Hematologic Diseases > Blood Protein Disorders > Paraproteinemias > Heavy Chain Disease

Immune System Diseases > Immunoproliferative Disorders > Paraproteinemias > Heavy Chain Disease

Heavy Chain Disease

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A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.

http://data.loterre.fr/ark:/67375/JVR-HXKCLLNP-D

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