: MeSH: Centromere Protein A

Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Poly-ADP-Ribose Binding Proteins > Centromere Protein A

Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Poly-ADP-Ribose Binding Proteins > Centromere Protein A

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Centromere Protein A

Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > Chromosomal Proteins, Non-Histone > Centromere Protein A

Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Chromosomal Proteins, Non-Histone > Centromere Protein A

Biological Factors > Antigens > Autoantigens > Centromere Protein A

Centromere Protein A

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A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.

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