Concept information
Término preferido
Colorectal Neoplasms, Hereditary Nonpolyposis
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Tipo
-
mesh:Descriptor
Definición
- A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer. HNPCC with no history of associated cancers.
Concepto genérico
Conceptos específicos
Etiquetas alternativas
- Familial Nonpolyposis Colon Cancer
- Hereditary Nonpolyposis Colorectal Neoplasms
En otras lenguas
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francés
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Tumeurs colo-rectales héréditaires sans polypose
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Tumeurs colorectales héréditaires non polyposiques
URI
http://data.loterre.fr/ark:/67375/JVR-J72D4TKD-M
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