Concept information
Término preferido
Progranulins
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Tipo
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mesh:Descriptor
Definición
- Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.
Concepto genérico
Conceptos específicos
Etiquetas alternativas
- 134710-81-9
- Acrogranin
- Granulin Precursor
- Granulin Precursor Protein
- PC Cell-Derived Growth Factor
- Proepithelin
- Progranulin
En otras lenguas
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francés
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134710-81-9
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Facteur de croissance dérivé des cellules PC
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Précurseur de granuline
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Proépithéline
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Progranuline
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Protéine précurseur de granuline
URI
http://data.loterre.fr/ark:/67375/JVR-K2JJG6MG-4
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