: MeSH: Neuroleptic Malignant Syndrome

Chemically-Induced Disorders > Poisoning > Neurotoxicity Syndromes > Neuroleptic Malignant Syndrome

Nervous System Diseases > Neurotoxicity Syndromes > Neuroleptic Malignant Syndrome

Nervous System Diseases > Central Nervous System Diseases > Brain Diseases > Basal Ganglia Diseases > Neuroleptic Malignant Syndrome

Neuroleptic Malignant Syndrome

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A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)

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