: MeSH: Axin Signaling Complex

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Axin Signaling Complex

Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Axin Signaling Complex

Macromolecular Substances > Multiprotein Complexes > Axin Signaling Complex

Axin Signaling Complex

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A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.

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