: MeSH: Trans-Splicing

Metabolism > RNA Processing, Post-Transcriptional > RNA Splicing > Trans-Splicing

Chemical Phenomena > Biochemical Phenomena > RNA Processing, Post-Transcriptional > RNA Splicing > Trans-Splicing

Genetic Phenomena > Gene Expression Regulation > RNA Processing, Post-Transcriptional > RNA Splicing > Trans-Splicing

Trans-Splicing

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The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.

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