: MeSH: Kernicterus

Nutritional and Metabolic Diseases > Metabolic Diseases > Brain Diseases, Metabolic > Kernicterus

Nervous System Diseases > Central Nervous System Diseases > Brain Diseases > Brain Diseases, Metabolic > Kernicterus

Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Infant, Newborn, Diseases > Erythroblastosis, Fetal > Kernicterus

Immune System Diseases > Erythroblastosis, Fetal > Kernicterus

Hemic and Lymphatic Diseases > Hematologic Diseases > Erythroblastosis, Fetal > Kernicterus

... > Female Urogenital Diseases and Pregnancy Complications > Pregnancy Complications > Fetal Diseases > Erythroblastosis, Fetal > Kernicterus

Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Fetal Diseases > Erythroblastosis, Fetal > Kernicterus

Pathological Conditions, Signs and Symptoms > Pathologic Processes > Hyperbilirubinemia > Kernicterus

Kernicterus

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A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)

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