: MeSH: Phase Variation

Genetic Phenomena > Genetic Variation > Phase Variation

Phase Variation

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An adaptive mechanism used by microbes to avoid detection by the host or adapt to changes in environment by randomly and rapidly switch on and off of a gene by various mechanisms between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS arises through rapid reversible mutations in the glpK gene through phase variation.

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