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Concept information

Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zidovudine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Thymidine > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Thymidine > Zidovudine
... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrimidines > Pyrimidine Nucleosides > Thymidine > Zidovudine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Pyrimidine Nucleosides > Thymidine > Zidovudine
... > Carbohydrates > Glycosides > Nucleosides > Pyrimidine Nucleosides > Thymidine > Zidovudine

Término preferido

Zidovudine  

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Tipo

  • mesh:Descriptor

Definición

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.

Concepto genérico

Etiquetas alternativas

  • 30516-87-1 (Zidovudine)
  • 3'-Azido-2',3'-Dideoxythymidine
  • 3'-Azido-3'-deoxythymidine
  • 4B9XT59T7S
  • Azidothymidine
  • AZT (Antiviral)
  • AZT Antiviral
  • AZT, Antiviral
  • Thymidine, 3'-azido-3'-deoxy-

En otras lenguas

  • Zidovudine

    francés

  • 3'-Azido-3'-désoxy-thymidine
  • 3'-Azido-3'-désoxythymidine
  • 30516-87-1 (Zidovudine)
  • 4B9XT59T7S
  • Azidothymidine
  • AZT (Azidothymidine)
  • Thymidine, 3'-azido-3'-deoxy-

URI

http://data.loterre.fr/ark:/67375/JVR-PLNR7NBH-G

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