Concept information
Término preferido
Clozapine
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Tipo
-
mesh:Descriptor
Definición
- A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Concepto genérico
Etiquetas alternativas
- 5786-21-0 (Clozapine)
- 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
- J60AR2IKIC
En otras lenguas
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francés
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5786-21-0 (Clozapine)
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5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
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J60AR2IKIC
URI
http://data.loterre.fr/ark:/67375/JVR-RHQSBTM2-S
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