Concept information
Término preferido
MicroRNAs
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Tipo
-
mesh:Descriptor
Definición
- Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing. The RNA transcript of the miRNA genes prior to processing to pre-miRNA. A class of microRNAs that regulate developmental timing. Precursors to miRNA generated from pri-miRNA. They are exported from the nucleus where they are further processed by Dicer RNase to generate mature miRNA.
Concepto genérico
Conceptos específicos
Etiquetas alternativas
- Micro RNA
- MicroRNA
- miRNA
- miRNAs
En otras lenguas
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francés
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miARN
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micro-ARN
URI
http://data.loterre.fr/ark:/67375/JVR-RPP5P6HF-L
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