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MicroRNAs  

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Tipo

  • mesh:Descriptor

Definición

  • Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing. The RNA transcript of the miRNA genes prior to processing to pre-miRNA. A class of microRNAs that regulate developmental timing. Precursors to miRNA generated from pri-miRNA. They are exported from the nucleus where they are further processed by Dicer RNase to generate mature miRNA.

Conceptos específicos

Etiquetas alternativas

  • Micro RNA
  • MicroRNA
  • miRNA
  • miRNAs

En otras lenguas

URI

http://data.loterre.fr/ark:/67375/JVR-RPP5P6HF-L

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