: MeSH: Gamma Secretase Inhibitors and Modulators

Chemical Actions and Uses > Pharmacologic Actions > Molecular Mechanisms of Pharmacological Action > Enzyme Inhibitors > Gamma Secretase Inhibitors and Modulators

Gamma Secretase Inhibitors and Modulators

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Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types.

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