: MeSH: Protein Phosphatase 2C

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Phosphoprotein Phosphatases > Protein Phosphatase 2C

Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Phosphoprotein Phosphatases > Protein Phosphatase 2C

... > Hydrolases > Esterases > Phosphoric Monoester Hydrolases > Phosphoprotein Phosphatases > Protein Phosphatase 2C

Protein Phosphatase 2C

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One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.

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