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Biological Factors > Toxins, Biological > Mycotoxins > Aflatoxins > Aflatoxin M1
... > Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Benzopyrans > Aflatoxins > Aflatoxin M1
... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrans > Benzopyrans > Aflatoxins > Aflatoxin M1

Término preferido

Aflatoxin M1  

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Tipo

  • mesh:Descriptor

Definición

  • A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).

Concepto genérico

Etiquetas alternativas

  • 25325-49-9 (cis(+-)-isomer)
  • 4-Hydroxyaflatoxin B1
  • 6795-23-9
  • Aflatoxin M(1)
  • Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-

En otras lenguas

  • Aflatoxine M1

    francés

  • 25325-49-9 (cis(+-)-isomer)
  • 4-Hydroxy-aflatoxine B1
  • 6795-23-9
  • Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-

URI

http://data.loterre.fr/ark:/67375/JVR-T72WT1C3-T

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