: MeSH: Tripartite Motif-Containing Protein 28

... > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > Tripartite Motif-Containing Protein 28

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Repressor Proteins > Tripartite Motif-Containing Protein 28

Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Repressor Proteins > Tripartite Motif-Containing Protein 28

Amino Acids, Peptides, and Proteins > Proteins > Tripartite Motif Proteins > Tripartite Motif-Containing Protein 28

Tripartite Motif-Containing Protein 28

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A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.

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