: MeSH: Dermatomyositis

Skin and Connective Tissue Diseases > Skin Diseases > Dermatomyositis

Musculoskeletal Diseases > Muscular Diseases > Myositis > Polymyositis > Dermatomyositis

... > Neuromuscular Diseases > Muscular Diseases > Myositis > Polymyositis > Dermatomyositis

Skin and Connective Tissue Diseases > Connective Tissue Diseases > Dermatomyositis

Dermatomyositis

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A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)

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