: MeSH: Presenilin-2

Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Presenilins > Presenilin-2

Presenilin-2

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Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

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