: MeSH: CLOCK Proteins

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Basic Helix-Loop-Helix Transcription Factors > CLOCK Proteins

Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Basic Helix-Loop-Helix Transcription Factors > CLOCK Proteins

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Circadian Rhythm Signaling Peptides and Proteins > CLOCK Proteins

Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Circadian Rhythm Signaling Peptides and Proteins > CLOCK Proteins

... > Acyltransferases > Acetyltransferases > Lysine Acetyltransferases > Histone Acetyltransferases > CLOCK Proteins

CLOCK Proteins

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Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.

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