Concept information
Término preferido
ATP Binding Cassette Transporter, Subfamily B
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Tipo
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mesh:Descriptor
Definición
- A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
Concepto genérico
Conceptos específicos
Etiquetas alternativas
- ATP Binding Cassette Transporter, Sub-Family B
- ATP-Binding Cassette, Sub-Family B Proteins
- Multidrug Resistance Proteins
- P-Glycoproteins
En otras lenguas
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francés
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Glycoprotéines P
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Protéines de résistance multidrogue
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Protéines de résistance multiple aux drogues
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Protéines de résistance multiple aux médicaments
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Sous-famille B de protéines à cassette de liaison à l'ATP
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Sous-famille B de protéines à cassette liant l'ATP
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Sous-famille B de transporteurs à cassette de liaison à l'ATP
URI
http://data.loterre.fr/ark:/67375/JVR-WDNTVV9S-2
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