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ATP Binding Cassette Transporter, Subfamily B  

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Tipo

  • mesh:Descriptor

Definición

  • A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Etiquetas alternativas

  • ATP Binding Cassette Transporter, Sub-Family B
  • ATP-Binding Cassette, Sub-Family B Proteins
  • Multidrug Resistance Proteins
  • P-Glycoproteins

En otras lenguas

  • francés

  • Glycoprotéines P
  • Protéines de résistance multidrogue
  • Protéines de résistance multiple aux drogues
  • Protéines de résistance multiple aux médicaments
  • Sous-famille B de protéines à cassette de liaison à l'ATP
  • Sous-famille B de protéines à cassette liant l'ATP
  • Sous-famille B de transporteurs à cassette de liaison à l'ATP

URI

http://data.loterre.fr/ark:/67375/JVR-WDNTVV9S-2

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