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... > Polycyclic Compounds > Polycyclic Aromatic Hydrocarbons > Naphthalenes > Tetrahydronaphthalenes > Podophyllotoxin > Etoposide
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Aromatic > Polycyclic Aromatic Hydrocarbons > Naphthalenes > Tetrahydronaphthalenes > Podophyllotoxin > Etoposide
... > Organic Chemicals > Hydrocarbons > Hydrocarbons, Cyclic > Hydrocarbons, Aromatic > Benzene Derivatives > Benzyl Compounds > Lignans > Podophyllotoxin > Etoposide
Carbohydrates > Glycosides > Glucosides > Etoposide

Término preferido

Etoposide  

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Tipo

  • mesh:Descriptor

Definición

  • A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Concepto genérico

Etiquetas alternativas

  • 100007-53-2 (alpha-D-glucopyranosyl isomer)
  • 33419-42-0 (Etoposide)
  • 6PLQ3CP4P3
  • 89301-95-1 ((5S)-isomer)
  • 96554-38-0 ((5a alpha)-isomer)
  • 96554-41-5 ((5a alpha,9 alpha)-isomer)
  • Demethyl Epipodophyllotoxin Ethylidine Glucoside
  • Eposide

En otras lenguas

  • Étoposide

    francés

  • 100007-53-2 (alpha-D-glucopyranosyl isomer)
  • 33419-42-0 (Etoposide)
  • 6PLQ3CP4P3
  • 89301-95-1 ((5S)-isomer)
  • 96554-38-0 ((5a alpha)-isomer)
  • 96554-41-5 ((5a alpha,9 alpha)-isomer)

URI

http://data.loterre.fr/ark:/67375/JVR-WN4RBMR3-B

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RDF/XML TURTLE JSON-LD Creado 25/7/75, última modificación 1/3/18