: MeSH: Anaphase-Promoting Complex-Cyclosome

... > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > Anaphase-Promoting Complex-Cyclosome

Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > Anaphase-Promoting Complex-Cyclosome

Anaphase-Promoting Complex-Cyclosome

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An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

http://data.loterre.fr/ark:/67375/JVR-WNTTPC8V-K

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