: MeSH: Glucose-6-Phosphate Isomerase

... > Enzymes > Isomerases > Intramolecular Oxidoreductases > Aldose-Ketose Isomerases > Glucose-6-Phosphate Isomerase

Glucose-6-Phosphate Isomerase

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An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA. A secreted form of glucose-6-phosphate isomerase.

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