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Concept information

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > DCC Receptor
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > DCC Receptor
Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Tumor Suppressor Proteins > DCC Receptor
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Netrin Receptors > DCC Receptor

Terme préférentiel

DCC Receptor  

Type

  • mesh:Descriptor

Définition

  • A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.

Concept générique

Synonyme(s)

  • DCC-Netrin-1 Receptor
  • DCC Tumor Suppressor Protein
  • Deleted in Colorectal Carcinoma Protein

Qualificatif(s) autorisé(s)

Traductions

  • Récepteur DCC

    français

  • Protéine DCC suppresseur de tumeur
  • Protéine délétée dans le carcinome colorectal
  • Protéine délétée dans les carcinomes colorectaux
  • Protéine suppresseur de tumeur DCC
  • Récepteur DCC-Netrin-1

URI

http://data.loterre.fr/ark:/67375/JVR-B6K5JX8Z-Z

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RDF/XML TURTLE JSON-LD Date de création 11/07/2017, dernière modification le 24/05/2017