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Concept information

... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structural Elements > Amino Acid Motifs > Immunoreceptor Tyrosine-Based Activation Motif
... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structure, Secondary > Amino Acid Motifs > Immunoreceptor Tyrosine-Based Activation Motif

Terme préférentiel

Immunoreceptor Tyrosine-Based Activation Motif  

Type

  • mesh:Descriptor

Définition

  • A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.

Concept générique

Synonyme(s)

  • Immune Receptor Tyrosine-Based Activation Motif
  • Immuno-Receptor Tyrosine-Based Activation Motif

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-BPP66K9M-6

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RDF/XML TURTLE JSON-LD Date de création 03/07/2012, dernière modification le 05/07/2016